Px
PeptideCalc
📈

GH Secretagogues

Growth hormone secretagogues stimulate the pituitary gland to release endogenous growth hormone — rather than replacing it like exogenous HGH. This preserves the natural pulsatile GH release pattern a...

Overview

Growth hormone secretagogues stimulate the pituitary gland to release endogenous growth hormone — rather than replacing it like exogenous HGH. This preserves the natural pulsatile GH release pattern and avoids many risks of HGH replacement. The two main classes are GHRH analogues (Tesamorelin, CJC-1295, Sermorelin — which increase the amplitude of GH pulses) and GHRPs (Ipamorelin, Hexarelin — which increase GH pulse frequency). Combining one from each class produces synergistic GH release.

Calculate Your Dose

Use our calculator for these peptides — presets auto-fill the math.

Open Calculator →

Tesamorelin

GHRH analogue, Egrifta

Mechanism

Full-length GHRH analogue. Stimulates pituitary somatotroph cells to release GH. More potent than Sermorelin with a longer half-life. FDA-approved for HIV lipodystrophy.

Benefits

  • ✓Increased GH and IGF-1 levels
  • ✓Visceral fat reduction (clinically proven)
  • ✓Improved body composition
  • ✓Better sleep quality
  • ✓Cognitive improvements in older adults

Dosing

1,000mcg/day SubQ. Usually injected before bed to align with natural GH pulsation.

Reconstitution

10mg + 2mL BAC = 5,000mcg/mL. Draw 20 units for 1,000mcg.

Cycle Length

Cycles of 3–6 months with 1–2 month breaks. Or continuous with regular IGF-1 monitoring.

Timing

Before bed (30 min before sleep) on empty stomach for best results.

Stacks Well With

Ipamorelin (synergistic stack), CJC-1295

Cautions

Can elevate IGF-1. Monitor IGF-1 levels quarterly. Avoid with active cancer.

Calculate Tesamorelin dose →

Ipamorelin

GHRP-3 analogue

Mechanism

Selective ghrelin receptor agonist (GHRP). Stimulates GH release without significantly raising cortisol or prolactin — making it the cleanest GHRP. Amplifies frequency of GH pulses.

Benefits

  • ✓Clean GH release (no cortisol elevation)
  • ✓Improved sleep architecture
  • ✓Body composition support
  • ✓Anti-aging effects
  • ✓Muscle recovery

Dosing

200–300mcg, injected 2–3x daily. Best doses: before bed, on waking, and pre-workout.

Reconstitution

10mg + 3mL BAC = 3,333mcg/mL. Draw 6 units for 200mcg, 9 units for 300mcg.

Cycle Length

3–6 months on, 1–2 months off.

Timing

Before bed (most important), morning on empty stomach, pre-workout. 30 min before eating.

Stacks Well With

Tesamorelin or CJC-1295 (synergistic — amplitude + frequency)

Cautions

Very well tolerated. May cause mild water retention at higher doses.

Calculate Ipamorelin dose →

CJC-1295 No DAC

Modified GRF 1-29, Mod GRF

Mechanism

Truncated GHRH analogue with 30-minute half-life (no DAC). Produces a clean GH pulse when combined with a GHRP. Preferred over DAC version for more natural pulsatile release.

Benefits

  • ✓Natural-feeling GH pulses
  • ✓Improved body composition
  • ✓Better sleep
  • ✓Recovery

Dosing

100–200mcg per injection, always combined with Ipamorelin or another GHRP.

Reconstitution

10mg + 3mL BAC = 3,333mcg/mL.

Cycle Length

Same as Ipamorelin — 3–6 months.

Timing

Injected simultaneously with Ipamorelin before bed (and other dosing times).

Stacks Well With

Ipamorelin (the classic combo)

Cautions

Must be combined with a GHRP for meaningful effect. CJC alone has limited effectiveness.

Calculate CJC-1295 No DAC dose →

Frequently Asked Questions