Peptide Stacking Guide
Peptides can be stacked (combined) when their mechanisms are complementary. Some combinations are synergistic — the combination produces more benefit than either alone. Here are the researched combos and what to avoid.
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Classic Healing Stack
BPC-157 + TB-500
• Mechanism synergy: BPC-157 promotes angiogenesis and gut healing; TB-500 promotes actin regulation and systemic cell migration
• Protocol: BPC-157 500mcg/day + TB-500 2mg 2x/week
• Or: Pre-mixed combo vial (5/5mg or 10/10mg)
• Duration: 6–12 weeks
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Classic GH Stack
Tesamorelin + Ipamorelin
• Mechanism synergy: GHRH (amplitude) + GHRP (frequency) = synergistic GH release
• Protocol: 1,000mcg Tesamorelin + 200–300mcg Ipamorelin, both injected before bed
• Duration: 3–6 months cycles
• Available as pre-mixed Tesamorelin/Ipamorelin combo vials
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Comprehensive Anti-Aging Stack
Epitalon (cycled) + MOTS-c + SS-31 + NAD+
• Epitalon: 500mcg/day × 10 days, 3x/year
• MOTS-c: 5mg 3x/week continuous
• SS-31: 5mg daily
• NAD+: 25–50mg 2–3x/week
• FOXO4-DRI: 5mg 3x/week × 10 days, 3–4x/year (senolytic cycles)
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What NOT to Stack
⚠️ Avoid these combinations:
• SS-31 + HGH gels: SS-31 and topical HGH gels can interfere with each other's mechanisms
• Zinc Thymulin + GHK-Cu (topical): These two topical peptides compete for the same copper-zinc binding sites — don't apply simultaneously. Separate by 4+ hours or rotate days.
• Multiple GLP-1 agonists: Don't combine Semaglutide + Retatrutide + Tirzepatide — excessive receptor stimulation and GI toxicity
• Cancer-concern peptides with active cancer: BPC-157, TB-500, GHK-Cu with active malignancy — discuss with oncologist first
Questions
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