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Immune Support Peptides

Immune peptides work through diverse mechanisms ā€” from thymus-derived peptides that calibrate T-cell function (Thymosin Alpha-1, Thymalin) to antimicrobial peptides that directly combat pathogens (LL-...

Overview

Immune peptides work through diverse mechanisms ā€” from thymus-derived peptides that calibrate T-cell function (Thymosin Alpha-1, Thymalin) to antimicrobial peptides that directly combat pathogens (LL-37) and anti-inflammatory neuropeptides (VIP, KPV). These compounds are used in research for immune reconstitution, chronic infection, MCAS, Lyme disease, and general immune optimization.

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Thymosin Alpha-1

TĪ±1, TA-1, Zadaxin

Mechanism

Thymus-derived peptide that modulates T-cell maturation, enhances dendritic cell function, and upregulates MHC class I expression. Used clinically for hepatitis B/C and cancer immunotherapy.

Benefits

  • āœ“T-cell immune reconstitution
  • āœ“Antiviral activity
  • āœ“Anti-tumor immune support
  • āœ“Immune modulation in autoimmunity
  • āœ“Improved response to vaccines

Dosing

Clinical dose: 1.6mg (1600mcg) 2x/week. Research: 100ā€“200mcg daily.

Reconstitution

10mg + 3mL BAC = 3,333mcg/mL.

Cycle Length

Acute protocols: 4ā€“6 weeks 2x/week. Ongoing: 2x/week indefinitely.

Timing

SubQ any time. Twice weekly (e.g., Mon/Thu).

Stacks Well With

LL-37, BPC-157, VIP

Cautions

Well-tolerated. Avoid with organ transplant (may enhance rejection of graft).

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LL-37

Human cathelicidin antimicrobial peptide, hCAP-18

Mechanism

Human cathelicidin. Directly kills bacteria, viruses, and fungi via membrane disruption. Also modulates immune signaling and wound healing.

Benefits

  • āœ“Broad-spectrum antimicrobial
  • āœ“Antiviral (including SARS-CoV-2 in vitro)
  • āœ“Biofilm disruption
  • āœ“Wound healing
  • āœ“Anti-inflammatory signaling

Dosing

50ā€“100mcg daily SubQ.

Reconstitution

5mg + 3mL BAC = 1,667mcg/mL.

Cycle Length

2ā€“4 week cycles.

Timing

Daily SubQ. Injection site may sting ā€” ice before injecting.

Stacks Well With

Thymosin Alpha-1, VIP

Cautions

Notable injection site pain. Ice the area first. Can cause local redness.

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VIP

Vasoactive Intestinal Peptide

Mechanism

Neuropeptide with widespread anti-inflammatory effects. Reduces cytokine production, promotes T-regulatory cells, and protects lung tissue. Key in MCAS and mold illness research.

Benefits

  • āœ“Anti-inflammatory
  • āœ“Lung protection
  • āœ“MCAS and mast cell modulation
  • āœ“Neuroprotective
  • āœ“Gastrointestinal motility support

Dosing

25ā€“100mcg SubQ or intranasal. Intranasal: 50mcg/nostril 2ā€“4x daily.

Reconstitution

5mg + 3mL BAC = 1,667mcg/mL.

Cycle Length

Ongoing use is researched. 30ā€“90 day cycles common.

Timing

Multiple times daily for MCAS. Single daily SubQ for general immune support.

Stacks Well With

BPC-157 (gut), Thymosin Alpha-1

Cautions

Can cause flushing and hypotension at higher doses. Start low.

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