Retatrutide
Triple agonist (GLP-1 / GIP / Glucagon)
Triple receptor agonist targeting GLP-1, GIP (glucose-dependent insulinotropic polypeptide), and glucagon receptors. The glucagon component adds significant energy expenditure boost on top of appetite suppression.
Dose
Start 500mcg/week
Cycle
Long-term use
Timing
Once weekly SubQ
Benefits & Effects
- ✓Up to 24% body weight reduction (phase 2 trials)
- ✓Strongest fat loss of any peptide class studied
- ✓Metabolic rate increase via glucagon action
- ✓Appetite suppression
Reconstitution & Dosing
Reconstitution
6mg + 2mL BAC = 3,000mcg/mL. 10mg + 2mL BAC = 5,000mcg/mL. 12mg + 2mL BAC = 6,000mcg/mL.
Dose
Start 500mcg/week. Titrate slowly every 4–8 weeks. Maximum studied dose: 12mg/week.
Cycle Length
Long-term use. Titrate up over 3–6 months.
Timing
Once weekly SubQ.
Calculate Retatrutide dose
Auto-fills your vial size, BAC water, and desired dose. Gets your exact syringe units.
Stacking
Generally used solo given its potency. May combine with Thymalin or immune peptides.
Cautions
More aggressive GI side effects than semaglutide. Titrate conservatively. Nausea, vomiting common at higher doses.
Frequently Asked Questions
What is Retatrutide used for?
Retatrutide is researched for: Up to 24% body weight reduction (phase 2 trials), Strongest fat loss of any peptide class studied, Metabolic rate increase via glucagon action, Appetite suppression. Triple receptor agonist targeting GLP-1, GIP (glucose-dependent insulinotropic polypeptide), and glucagon receptors. The glucagon component adds significant energy expenditure boost on top of appetite suppression.
What is the standard dosing for Retatrutide?
Start 500mcg/week. Titrate slowly every 4–8 weeks. Maximum studied dose: 12mg/week.
How do you reconstitute Retatrutide?
6mg + 2mL BAC = 3,000mcg/mL. 10mg + 2mL BAC = 5,000mcg/mL. 12mg + 2mL BAC = 6,000mcg/mL. Store reconstituted peptide refrigerated at 2–8°C for up to 60–90 days.
What peptides stack well with Retatrutide?
Generally used solo given its potency. May combine with Thymalin or immune peptides.
Are there any cautions with Retatrutide?
More aggressive GI side effects than semaglutide. Titrate conservatively. Nausea, vomiting common at higher doses.
What is the cycle length for Retatrutide?
Long-term use. Titrate up over 3–6 months. Timing: Once weekly SubQ.