Px
PeptideCalc

MOTS-c

Mitochondrial Open Reading Frame of the 12S rRNA-c

Peptide encoded in mitochondrial DNA. Acts as a mitochondrial hormone, improving insulin sensitivity, activating AMPK, and mimicking some effects of exercise. Improves metabolic flexibility.

Dose

5mg, 2–3x per week

Cycle

Can be used long-term

Timing

Pre-workout timing may enhance metabolic effects

Benefits & Effects

  • Exercise-mimicking metabolic effects
  • Improved insulin sensitivity
  • Weight management support
  • Mitochondrial health
  • Reduced age-related decline

Reconstitution & Dosing

Reconstitution

10mg + 1mL BAC = 10,000mcg/mL. 30mg + 3mL BAC = 10,000mcg/mL.

Dose

5mg, 2–3x per week. SubQ or IM.

Cycle Length

Can be used long-term. Common: 8–12 weeks on, 4 off.

Timing

Pre-workout timing may enhance metabolic effects.

Calculate MOTS-c dose

Auto-fills your vial size, BAC water, and desired dose. Gets your exact syringe units.

Open Calculator →

Stacking

SS-31 (mitochondrial stack), NAD+, Epitalon

Cautions

Well-tolerated. No significant adverse effects in research.

Frequently Asked Questions

What is MOTS-c used for?

MOTS-c is researched for: Exercise-mimicking metabolic effects, Improved insulin sensitivity, Weight management support, Mitochondrial health, Reduced age-related decline. Peptide encoded in mitochondrial DNA. Acts as a mitochondrial hormone, improving insulin sensitivity, activating AMPK, and mimicking some effects of exercise. Improves metabolic flexibility.

What is the standard dosing for MOTS-c?

5mg, 2–3x per week. SubQ or IM.

How do you reconstitute MOTS-c?

10mg + 1mL BAC = 10,000mcg/mL. 30mg + 3mL BAC = 10,000mcg/mL. Store reconstituted peptide refrigerated at 2–8°C for up to 60–90 days.

What peptides stack well with MOTS-c?

SS-31 (mitochondrial stack), NAD+, Epitalon

Are there any cautions with MOTS-c?

Well-tolerated. No significant adverse effects in research.

What is the cycle length for MOTS-c?

Can be used long-term. Common: 8–12 weeks on, 4 off. Timing: Pre-workout timing may enhance metabolic effects.