FOXO4-DRI
FOXO4-p53 interfering peptide
Senolytic peptide that disrupts the FOXO4-p53 interaction that keeps senescent (zombie) cells alive. Forces apoptosis (programmed cell death) in senescent cells while leaving healthy cells unharmed.
Dose
5mg EOD or 3x/week
Cycle
10-day cycles, 4–6 times per year
Timing
Any time SubQ
Benefits & Effects
- ✓Selective elimination of senescent cells
- ✓Physical rejuvenation in animal models
- ✓Improved fitness and fur density in aged mice
- ✓Reduced SASP (senescence-associated secretory phenotype)
Reconstitution & Dosing
Reconstitution
10mg + 1mL BAC = 10,000mcg/mL.
Dose
5mg EOD or 3x/week. Short cycles: 10 days on, 2 weeks off.
Cycle Length
10-day cycles, 4–6 times per year.
Timing
Any time SubQ.
Calculate FOXO4-DRI dose
Auto-fills your vial size, BAC water, and desired dose. Gets your exact syringe units.
Stacking
Epitalon, NAD+, MOTS-c (comprehensive longevity stack)
Cautions
Senolytic activity is powerful — some researchers experience temporary fatigue/malaise as senescent cells clear. Start with lower dose. Not for use with active cancer treatment.
Frequently Asked Questions
What is FOXO4-DRI used for?
FOXO4-DRI is researched for: Selective elimination of senescent cells, Physical rejuvenation in animal models, Improved fitness and fur density in aged mice, Reduced SASP (senescence-associated secretory phenotype). Senolytic peptide that disrupts the FOXO4-p53 interaction that keeps senescent (zombie) cells alive. Forces apoptosis (programmed cell death) in senescent cells while leaving healthy cells unharmed.
What is the standard dosing for FOXO4-DRI?
5mg EOD or 3x/week. Short cycles: 10 days on, 2 weeks off.
How do you reconstitute FOXO4-DRI?
10mg + 1mL BAC = 10,000mcg/mL. Store reconstituted peptide refrigerated at 2–8°C for up to 60–90 days.
What peptides stack well with FOXO4-DRI?
Epitalon, NAD+, MOTS-c (comprehensive longevity stack)
Are there any cautions with FOXO4-DRI?
Senolytic activity is powerful — some researchers experience temporary fatigue/malaise as senescent cells clear. Start with lower dose. Not for use with active cancer treatment.
What is the cycle length for FOXO4-DRI?
10-day cycles, 4–6 times per year. Timing: Any time SubQ.